Purinergic Receptors: Key Mediators of HIV-1 infection and inflammation

Purinergic Receptors: Key Mediators of HIV-1 infection and inflammation

Blog Article

Human immunodeficiency virus (HIV-1) causes a chronic infection that afflicts more than 38 million individuals worldwide.While the infection can be suppressed with potent anti-retroviral therapies, individuals infected with HIV have elevated levels of inflammation as indicated cashel tail bag by increased T cell activation, soluble biomarkers, and associated morbidity and mortality.A single mechanism linking HIV pathogenesis to this inflammation has yet to be identified.Purinergic receptors are known to mediate inflammation and have been shown to be required for HIV-1 infection at the level of HIV-1 membrane black mustang with pink stripes fusion.

Here we review the literature on the role of purinergic receptors in HIV-1 infection and associated inflammation and describe a role for these receptors as potential therapeutic targets.